GUANIDINE HYDROTHIOCYANATE
Guanidine thiocyanate
CAS: 593-84-0
Molecular Formula: CH5N3.CHNS
GUANIDINE HYDROTHIOCYANATE - Names and Identifiers
| Name | Guanidine thiocyanate |
| Synonyms | GTC GUANIDINE RHODANIDE Guanidine thiocyanate GUANIDINE THIOCYANATE GUANIDINIUM THIOCYANATE Guanidine isothiocyanate GUANIDINE ISOTHIOCYANATE GUANIDINE MONOTHIOCYANATE Guanidinium Isothiocyanate GUANIDINIUM ISOTHIOCYANATE GUANIDINE HYDROTHIOCYANATE 2-(cyanosulfanyl)guanidine |
| CAS | 593-84-0 |
| EINECS | 209-812-1 |
| InChI | InChI=1/C2H4N4S/c3-1-7-6-2(4)5/h(H4,4,5,6) |
| InChIKey | ZJYYHGLJYGJLLN-UHFFFAOYSA-N |
GUANIDINE HYDROTHIOCYANATE - Physico-chemical Properties
| Molecular Formula | CH5N3.CHNS |
| Molar Mass | 118.16 |
| Density | 1.103g/mLat 20°C |
| Melting Point | 120-122°C(lit.) |
| Boling Point | 290.6°C at 760 mmHg |
| Flash Point | 129.5°C |
| Water Solubility | Soluble in water and ethanol |
| Solubility | H2O: 6M at20°C, clear, colorless |
| Vapor Presure | 0Pa at 20℃ |
| Appearance | White crystal or crystalline powder |
| Specific Gravity | 1.152 |
| Color | White or colorless |
| Odor | Odorless |
| BRN | 3563461 |
| pKa | 12.5[at 20 ℃] |
| PH | 4.8-6.0 (1420g/l, H2O, 20℃)(saturated solution) |
| Storage Condition | 20-25°C |
| Stability | Stability Stable, but light sensitive. Incompatible with acids (contact releases very toxic gas), strong oxidising agents. |
| Sensitive | Light Sensitive |
| Refractive Index | n20/D 1.482 |
| MDL | MFCD00013027 |
| Physical and Chemical Properties | Melting point 118-122°C |
| Use | Mainly used in biological medicine, chemical reagents, etc |
GUANIDINE HYDROTHIOCYANATE - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R32 - Contact with acids liberates very toxic gas R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S13 - Keep away from food, drink and animal foodstuffs. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 1759 |
| WGK Germany | 2 |
| RTECS | XL1225000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 29252000 |
| Hazard Class | 8 |
| Packing Group | III |
GUANIDINE HYDROTHIOCYANATE - Reference
| Reference Show more | 1. Zhang man-hui, Zhao Hong-Hui, Wang Cai-Xia, Wang Xiaoyu, Hou Jia, Zhang Junfeng, Xu Guanglan. Establishment of PCR-based method for genomic extraction from Crested Ibis feces [J]. Hubei Journal of Animal Husbandry and Veterinary Medicine, 2020,41(08):5-7 14. |
GUANIDINE HYDROTHIOCYANATE - Reference Information
| pH range of acid-base indicator discoloration | 4.8 - 6.0 |
| LogP | -1.5--1.42 at 20℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | guanidine isothiocyanate is white crystalline, melting point 116~121 ℃,20 ℃, the pH value of 6mol/L in water is 4.5~6, and the solubility is completely dissolved. It is a kind of coupling agent, is a kind of strong protein denaturing agent, can dissolve the protein, and make the protein secondary structure disappear, cell structure degradation, nuclear protein quickly separated from nucleic acid. For denaturation and lysis of cells; Extraction of rna and dna, RNase and DNase-free enzyme activity. |
| Use | guanidine thiocyanate can be used as a Biochemical reagent and a pharmaceutical intermediate. It is used for degreasing in oil industry, as a strong lipid degradation agent in daily chemical industry, and as a cell membrane breaking agent in biological pharmacy. mainly used in biological medicine, chemical reagents, etc. Chaotropic agent and strong denaturant, used for denaturation and lysis of cells; Extraction of RNA and DNA. |
| principle of action | guanidine isothiocyanate-phenol method principle of rna extraction: guanidinium Isothiocyanate and B- mercaptoethanol together inhibit the activity of rnase, while guanidinium Isothiocyanate and sodium dodecylsarcosine work together to denature proteins, thereby releasing rna; dna dissociation rarely occurs under acidic conditions, denaturation with the protein is precipitated and the rna is dissolved in the supernatant. |
| Research use | guanidine thiocyanate has been used: • lysis of colorectal adenocarcinoma cell lines prior to RNA isolation • As a PCR inhibitor for triple mitochondrial DNA (mtDNA) qPCR detection guanidinium thiocyanate is a denaturant, commonly used for RNA isolation. It is used as a storage buffer for whole blood samples. Guanidinium thiocyanate inactivates nucleases and is ideal for storing and freezing stool samples for DNA studies. Use |
| application in the field of chemical depilatory agent | chemical depilatory agent is a kind of soft hair, within 2~6min can be wiped or rinsed off the hair removal agent. Since the composition of the hair shaft is similar to that of the skin, chemical hair removal agents will inevitably damage the skin. Therefore, hair removal agents are classified as special purpose cosmetics. mercaptoacetic acid is the main depilatory agent nowadays, which gradually replaces sulfide depilatory agent. Depilatory actives used in such depilatory agents are thioglycolic acid and salts thereof, mercaptopropionic acid and salts thereof, and mercaptolactic acid and salts thereof. From the performance and price considerations, mainly used thioglycolic acid and its salts for hair removal active. The application of some Swelling agents helps to speed up the depilatory action of the mercapto compound depilatory agent, thereby reducing irritation to the skin. Such swelling agents include melamine, dicyandiamide or a mixture of both (w = 0.5% -2%), thiourea, potassium thiocyanate, guanidine thiocyanate and PVP copolymers. |
| preparation method | A preparation method of guanidine thiocyanate, which has the following process flow:(1) guanidine carbonate and ammonium sulfate in a weight ratio of 2: 1 were put into a reaction kettle and reacted at 45-95 ° C. For 1.5 hours to obtain crude guanidine thiocyanate. (2) dissolution, at room temperature, according to the ratio of 0.5: 1 guanidine thiocyanate crude soluble in water;(3) filtration, the raw materials and reaction by-products and other impurities with the method of filtration;(4) dehydration, and dehydration of the filtered mother liquor at high temperature;(5) crystallization, cooling of the solution, and concentration of the crystals to obtain guanidine thiocyanate of high purity. |
Last Update：2024-04-09 02:00:09
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